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Article

Comparative Analysis of Protein Folding Stability-Based Profiling Methods for Characterization of Biological Phenotypes.

Journal of the American Society for Mass Spectrometry - 1 Mar 2023

Bailey Morgan A, Tang Yun, Park Hye-Jin, Fitzgerald Michael C

Abstract excerpt

Recently, a new suite of mass spectrometry-based proteomic methods has been developed that enables evaluation of protein folding stability on the proteomic scale. These methods utilize chemical and thermal denaturation approaches (SPROX and TPP, respectively) as well as proteolysis strategies (DARTS, LiP, and PP) to assess protein folding stability. The analytical capabilities of these technique have been...

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Identifiers

PMID: 36802530
DOI: 10.1021/jasms.2c00248
PMCID: PMC10164353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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