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Article

Analysis of Brain Protein Stability Changes in a Mouse Model of Alzheimer's Disease.

Journal of proteome research - 4 Oct 2024

Tang Yun, Park Hye-Jin, Li Shengyu, Fitzgerald Michael C

Abstract excerpt

The stability of proteins from rates of oxidation (SPROX), thermal proteome profiling (TPP), and limited proteolysis (LiP) techniques were used to profile the stability of ∼2500 proteins in hippocampus tissue cell lysates from 2- and 8-months-old wild-type (C57BL/6J; n = 7) and transgenic (5XFAD; n = 7) mice with five Alzheimer's disease (AD)-linked mutations. Approximately 200-500 protein hits with AD-related...

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Identifiers

PMID: 39292827
DOI: 10.1021/acs.jproteome.4c00406
PMCID: PMC12129621

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