Article
Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens.
Proceedings of the National Academy of Sciences of the United States of America - 8 Sept 2020
Burnett Deborah L, Schofield Peter, Langley David B, Jackson Jennifer, Bourne Katherine, Wilson Emily, Porebski Benjamin T, Buckle Ashley M, Brink Robert, Goodnow Christopher C, Christ Daniel
Abstract excerpt
Conformational diversity and self-cross-reactivity of antigens have been correlated with evasion from neutralizing antibody responses. We utilized single cell B cell sequencing, biolayer interferometry and X-ray crystallography to trace mutation selection pathways where the antibody response must resolve cross-reactivity between foreign and self-proteins bearing near-identical contact surfaces, but differing in...
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