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A high‐throughput shotgun mutagenesis approach to mapping B‐cell antibody epitopes

22 May 2014

Abstract excerpt

Characterizing the binding sites of monoclonal antibodies (mAbs) on protein targets, their 'epitopes', can aid in the discovery and development of new therapeutics, diagnostics and vaccines. However, the speed of epitope mapping techniques has not kept pace with the increasingly large numbers of mAbs being isolated. Obtaining detailed epitope maps for functionally relevant antibodies can be challenging,...

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PMID: 24854488
DOI: 10.1111/imm.12323

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