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MitoSort: Robust Demultiplexing of Pooled Single-cell Genomic Data Using Endogenous Mitochondrial Variants.

Genomics, proteomics & bioinformatics - 3 Dec 2024

Tang Zhongjie, Zhang Weixing, Shi Peiyu, Li Sijun, Li Xinhui, Li Yueming, Xu Yicong, Shu Yaqing, Hu Zheng, Xu Jin

Abstract excerpt

Multiplexing across donors has emerged as a popular strategy to increase throughput, reduce costs, overcome technical batch effects, and improve doublet detection in single-cell genomic studies. To eliminate additional experimental steps, endogenous nuclear genome variants are used for demultiplexing pooled single-cell RNA sequencing (scRNA-seq) data by several computational tools. However, these tools have...

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PMID: 39404807
DOI: 10.1093/gpbjnl/qzae073
PMCID: PMC11671100

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