Article
Correlations between the NMR Lipoprotein Profile, APOE Genotype, and Cholesterol Efflux Capacity of Fasting Plasma from Cognitively Healthy Elderly Adults.
International journal of molecular sciences - 22 Jan 2023
de Rojas Itziar, Del Barrio Laura, Hernández Isabel, Montrreal Laura, García-González Pablo, Marquié Marta, Valero Sergi, Cano Amanda, Orellana Adelina, Boada Mercè, Mañes Santos, Ruiz Agustín
Abstract excerpt
Cholesterol efflux capacity (CEC) is of interest given its potential relationship with several important clinical conditions including Alzheimer's disease. The inactivation of the APOE locus in mouse models supports the idea that it is involved in determining the CEC. With that in mind, we examine the impact of the plasma metabolome profile and the APOE genotype on the CEC in cognitively healthy elderly subjects....
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