Article
Associations of APOE variants with sphingomyelin and cholesterol metabolites across the life-course in diverse populations.
Metabolomics : Official journal of the Metabolomic Society - 7 May 2025
Lee Sanghun, Kelly Rachel S, Chen Yulu, Waqas Mohammad, Mendez Kevin M, Hecker Julian, Hahn Georg, Lutz Sharon M, Celedón Juan C, Clish Clary B, Litonjua Augusto A, Chen Qingwen, McGeachie Michael, Choi Younjung, Weiss Scott T, Tanzi Rudolph E, Lange Christoph, Prokopenko Dmitry, Lasky-Su Jessica A
Abstract excerpt
INTRODUCTION: Two alleles (ε2 and ε4) in the APOE gene are known to be strongly associated with lipid metabolism disorders, such as dyslipidemia, which are important risk factors for the development of cardiovascular diseases. While prior research has largely centered on adult populations, establishing APOE-lipid associations in infants, children, and adolescents-especially those from historically understudied...
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