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The effect of apolipoprotein E polymorphism on serum metabolome – a population-based 10-year follow-up study

24 Jan 2019

Abstract excerpt

Apolipoprotein E (apoE) is the key regulator of plasma lipids, mediating altered functionalities in lipoprotein metabolism - affecting the risk of coronary artery (CAD) and Alzheimer's diseases, as well as longevity. Searching pathways influenced by apoE prior to adverse manifestations, we utilized a metabolome dataset of 228 nuclear-magnetic-resonance-measured serum parameters with a 10-year follow-up from the...

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PMID: 30679475
DOI: 10.1038/s41598-018-36450-9

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