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Article

Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy.

Journal of molecular and cellular cardiology - 1 Mar 2011

Chen Xiongwen, Nakayama Hiroyuki, Zhang Xiaoying, Ai Xiaojie, Harris David M, Tang Mingxin, Zhang Hongyu, Szeto Christopher, Stockbower Kathryn, Berretta Remus M, Eckhart Andrea D, Koch Walter J, Molkentin Jeffery D, Houser Steven R

Abstract excerpt

Pathological cardiac hypertrophy (PCH) is associated with the development of arrhythmia and congestive heart failure. While calcium (Ca(2+)) is implicated in hypertrophic signaling pathways, the specific role of Ca(2+) influx through the L-type Ca(2+) channel (I(Ca-L)) has been controversial and is the topic of this study. To determine if and how sustained increases in I(Ca-L) induce PCH, transgenic mouse models...

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Identifiers

PMID: 21111744
DOI: 10.1016/j.yjmcc.2010.11.012
PMCID: PMC3035763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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