Article

Optimized protocols for commonly-used murine models of heart failure with preserved ejection fraction

2025-01-25

Abstract excerpt

<h4>Background</h4> HFpEF is a leading cause of death worldwide and clinically relevant preclinical models are required to identify new therapeutic targets. The most clinically representative murine models of heart failure with preserved ejection fraction (HFpEF) in common use include a “2-hit” model combining metabolic stress with hypertension (high-fat diet [HFD] + N(gamma)-nitro-L-arginine methyl ester [L-NAME...

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Literature Corpus work: 566468b1-9900-5f36-a672-eae0f5e6f6ef
DOI: 10.1101/2025.01.22.634221

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