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A fetal tumor suppressor axis abrogates MLL-fusion-driven acute myeloid leukemia

1 Feb 2023

Abstract excerpt

MLL-rearrangements (MLL-r) are recurrent genetic events in acute myeloid leukemia (AML) and frequently associate with poor prognosis. In infants, MLL-r can be sufficient to drive transformation. However, despite the prenatal origin of MLL-r in these patients, congenital leukemia is very rare with transformation usually occurring postnatally. The influence of prenatal signals on leukemogenesis, such as those...

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PMID: 36763502
DOI: 10.1016/j.celrep.2023.112099

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