Article
Dissecting the early steps of MLL induced leukaemogenic transformation using a new mouse model of AML
2019-01-01
Abstract excerpt
To maintain a balanced production of all mature haematopoietic lineages and at the same time secure a stem cell reservoir, intricate regulatory programs have evolved to control multi-lineage differentiation and self-renewal in haematopoietic stem and progenitor cells. Leukaemogenic mutations commonly disrupt these regulatory programs causing a block in differentiation with simultaneous enhancement of proliferation...
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Identifiers and source
- Literature Corpus work
- 2789804e-17f5-5d37-b295-0e27cec85586
- DOI
- 10.17863/cam.37920