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Hematopoietic Stem Cells Are Intrinsically Protected against MLL-ENL-Mediated Transformation

1 Nov 2014

Abstract excerpt

Studies of developmental pathways of hematopoietic stem cells (HSCs) have defined lineage relationships throughout the blood system. This is relevant to acute myeloid leukemia (AML), where aggressiveness and therapeutic responsiveness can be influenced by the initial stage of transformation. To address this, we generated a mouse model in which the mixed-lineage leukemia/eleven-nineteen-leukemia (MLL-ENL)...

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PMID: 25456127
DOI: 10.1016/j.celrep.2014.10.036

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