Article
Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer.
Cancer cell - 1 May 2003
Forster Alan, Pannell Richard, Drynan Lesley F, McCormack Matthew, Collins Emma C, Daser Angelika, Rabbitts Terence H
Abstract excerpt
The etiology of human tumors often involves chromosomal translocations. Models that emulate translocations are essential to understanding the determinants of frank malignancy, those dictating the restriction of translocations to specific lineages, and as a basis for development of rational therapeutic methods. We demonstrate that developmentally regulated Cre-loxP-mediated interchromosomal recombination between...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.