The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.

doi:10.1172/JCI35901

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Article

The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.

The Journal of clinical investigation - 1 Apr 2009

Mercher Thomas, Raffel Glen D, Moore Sandra A, Cornejo Melanie G, Baudry-Bluteau Dominique, Cagnard Nicolas, Jesneck Jonathan L, Pikman Yana, Cullen Dana, Williams Ifor R, Akashi Koichi, Shigematsu Hirokazu, Bourquin Jean-Pierre, Giovannini Marco, Vainchenker William, Levine Ross L, Lee Benjamin H, Bernard Olivier A, Gilliland D Gary

Abstract excerpt

Acute megakaryoblastic leukemia (AMKL) is a form of acute myeloid leukemia (AML) associated with a poor prognosis. The genetics and pathophysiology of AMKL are not well understood. We generated a knockin mouse model of the one twenty-two-megakaryocytic acute leukemia (OTT-MAL) fusion oncogene that results from the t(1;22)(p13;q13) translocation specifically associated with a subtype of pediatric AMKL. We report...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19287095
DOI: 10.1172/JCI35901
PMCID: PMC2662544

Genes

MAL
RBPJ
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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