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Article

LIN28B overexpression defines a novel fetal-like subgroup of juvenile myelomonocytic leukemia

28 Dec 2015

Abstract excerpt

Juvenile myelomonocytic leukemia (JMML) is a rare and aggressive stem cell disease of early childhood. RAS activation constitutes the core component of oncogenic signaling. In addition, leukemic blasts in one-fourth of JMML patients present with monosomy 7, and more than half of patients show elevated age-adjusted fetal hemoglobin (HbF) levels. Hematopoietic stem cell transplantation is the current standard of...

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PMID: 26712910
DOI: 10.1182/blood-2015-09-667808

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