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Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation

26 Feb 2011

Abstract excerpt

Disruptor of telomeric silencing 1-like (Dot1l) is a histone 3 lysine 79 methyltransferase. Studies of constitutive Dot1l knockout mice show that Dot1l is essential for embryonic development and prenatal hematopoiesis. DOT1L also interacts with translocation partners of Mixed Lineage Leukemia (MLL) gene, which is commonly translocated in human leukemia. However, the requirement of Dot1l in postnatal hematopoiesis...

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PMID: 21398221
DOI: 10.1182/blood-2010-12-327668

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Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocationPMID 21398221Read ↗

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