Article

Fetal context conveys heritable protection against MLL-rearranged leukemia that depends on MLL3

2025-03-14

Abstract excerpt

<h4>ABSTRACT</h4> MLL rearrangements ( MLL r) are the most common cause of congenital and infant leukemias. MLL r arise prior to birth and require few cooperating mutations for transformation, yet congenital leukemias are 10-fold less common than infant leukemias and >100-fold less common than childhood leukemias overall. This raises the question of whether mechanisms exist to suppress leukemic transformation d...

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Literature Corpus work: c5518dd0-de87-5921-9cf4-2d7f68574ff0
DOI: 10.1101/2025.03.11.642680

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