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LIN28B promotes differentiation of fully transformed AML cells but is dispensable for fetal leukemia suppression

6 Feb 2024

Abstract excerpt

Infant leukemias present within the first year of life as either acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML). A majority are driven by KMT2A/MLL rearrangements (henceforth MLLr) that arise before birth [ 1 , 2 ]. Aside from MLLr, infant leukemias harbor few additional cooperating mutations [ 3 , 4 ]. Thus, the threshold of genetic change required for infant leukemia initiation, and the time...

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PMID: 38321106
DOI: 10.1038/s41375-024-02167-0

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