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Structure of Adeno-Associated Virus Serotype 5

11 Mar 2004

Abstract excerpt

Adeno-associated virus serotype 5 (AAV5) requires sialic acid on host cells to bind and infect. Other parvoviruses, including Aleutian mink disease parvovirus (ADV), canine parvovirus (CPV), minute virus of mice, and bovine parvovirus, also bind sialic acid. Hence, structural homology may explain this functional homology. The amino acids required for CPV sialic acid binding map to a site at the icosahedral...

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PMID: 15016858
DOI: 10.1128/jvi.78.7.3361-3371.2004

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