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Targeting Cbl-b in cancer immunotherapy

1 Feb 2023

Abstract excerpt

Cancer immunotherapy with immune-checkpoint blockade has improved the outcomes of patients with various malignancies, yet a majority do not benefit or develop resistance. To address this unmet need, efforts across the field are targeting additional coinhibitory receptors, costimulatory proteins, and intracellular mediators that could prevent or bypass anti-PD1 resistance mechanisms. The CD28 costimulatory pathway...

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PMID: 36750253
DOI: 10.1136/jitc-2022-006007

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