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Article

Cbl-b inhibition promotes less differentiated phenotypes of T cells with enhanced cytokine production.

Cellular immunology - 1 Jan 2024

Wang Junfan, Han XiaoJian, Hao Yanan, Chen Siyin, Pang Bo, Zou Lin, Han Xiaxia, Wang Wang, Liu Li, Shen Meiying, Jin Aishun

Abstract excerpt

For adoptive therapy with T cell receptor engineered T (TCR-T) cells, the quantity and quality of the final cell product directly affect their anti-tumor efficacy. The post-transfer efficacy window of TCR-T cells is keen to optimizing attempts during the manufacturing process. Cbl-b is a E3 ubiquitin ligase previously shown with critical negative impact in T cell functions. This study investigated whether...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphocyte Activation

Share to Phospholipase C gamma

Share to Proto-Oncogene Proteins c-cbl

Share to Receptors, Antigen, T-Cell

Share to ZAP-70 Protein-Tyrosine Kinase

Source

Identifiers

PMID: 39186873
DOI: 10.1016/j.cellimm.2024.104863

Genes

ZAP70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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