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Article

Considering B7-CD28 as a family through sequence and structure

17 Jun 2019

Abstract excerpt

With the emergence of immuno-oncology, new therapeutic agents that modulate immune activation and regulation are being used to treat cancer patients with durable response. It is well known that following T-cell receptor (TCR) activation, many co-receptors can augment or suppress the TCR signal, and therapeutically targeting these co-receptors has proven effective. The B7-CD28 family is comprised of such...

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PMID: 31208204
DOI: 10.1177/1535370219855970

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