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Article

Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells.

The Journal of experimental medicine - 16 Apr 2007

Loeser Stefanie, Loser Karin, Bijker Martijn S, Rangachari Manu, van der Burg Sjoerd H, Wada Teiji, Beissert Stefan, Melief Cornelis J M, Penninger Josef M

Abstract excerpt

The concept of tumor surveillance implies that specific and nonspecific components of the immune system eliminate tumors in the early phase of malignancy. Understanding the biochemical mechanisms of tumor immunosurveillance is of paramount significance because it might allow one to specifically modulate spontaneous antitumor activity. We report that inactivation of the E3 ligase Casitas B cell lymphoma-b (Cbl-b)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17403934
DOI: 10.1084/jem.20061699
PMCID: PMC2118550

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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