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E3 ligase casitas B-lineage lymphoma-b modulates peripheral T-cell tolerance via PI3K signaling in patients with immune thrombocytopenia

2023-03-29

Abstract excerpt

<h4>Background: </h4> The E3 ubiquitin ligase casitas B-lineage lymphoma-b (CBLB) is a newly identified component of the ubiquitin-dependent protein degradation system and is thought to be an important negative regulator of immune cells. CBLB is essential for establishing a threshold for T cell activation and for regulating peripheral T cell tolerance through various mechanisms. However, the role of CBLB in the pa...

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Literature Corpus work
4fb79a97-7ed7-5fec-b891-05f82fece1a7
DOI
10.21203/rs.3.rs-2741491/v1
Open publication

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E3 ligase casitas B-lineage lymphoma-b modulates peripheral T-cell tolerance via PI3K signaling in patients with immune thrombocytopeniaDOI 10.21203/rs.3.rs-2741491/v1
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