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Article

Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells.

Nature communications - 15 Sept 2021

Arsic Nikola, Slatter Tania, Gadea Gilles, Villain Etienne, Fournet Aurelie, Kazantseva Marina, Allemand Frédéric, Sibille Nathalie, Seveno Martial, de Rossi Sylvain, Mehta Sunali, Urbach Serge, Bourdon Jean-Christophe, Bernado Pau, Kajava Andrey V, Braithwaite Antony, Roux Pierre

Abstract excerpt

The p53 isoform, Δ133p53β, is critical in promoting cancer. Here we report that Δ133p53β activity is regulated through an aggregation-dependent mechanism. Δ133p53β aggregates were observed in cancer cells and tumour biopsies. The Δ133p53β aggregation depends on association with interacting partners including p63 family members or the CCT chaperone complex. Depletion of the CCT complex promotes accumulation of...

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Identifiers

PMID: 34526502
DOI: 10.1038/s41467-021-25550-2
PMCID: PMC8443592

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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