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Article

Alterations of ATG4A and LC3B in neurons derived from Alzheimer's disease patients.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Apr 2023

Shirotani Keiro, Watanabe Kaori, Hatta Daisuke, Kutoku Yumiko, Ohsawa Yutaka, Sunada Yoshihide, Kondo Takayuki, Inoue Haruhisa, Iwata Nobuhisa

Abstract excerpt

We investigated the alterations in autophagy-related molecules in neurons differentiated from induced pluripotent stem cells obtained from patients with Alzheimer's disease (AD). Consistent with our previous microarray data, ATG4A protein was upregulated in the neurons derived from a familial AD patient with an APP-E693Δ mutation who showed accumulation of intracellular amyloid β peptide (Aβ). This upregulation...

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PMID: 36719634
DOI: 10.1111/gtc.13010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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