Article
Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum.
PLoS pathogens - 1 Jan 2023
Kucharski Michal, Wirjanata Grennady, Nayak Sourav, Boentoro Josephine, Dziekan Jerzy Michal, Assisi Christina, van der Pluijm Rob W, Miotto Olivo, Mok Sachel, Dondorp Arjen M, Bozdech Zbynek
Abstract excerpt
Resistance of the human malaria parasites, Plasmodium falciparum, to artemisinins is now fully established in Southeast Asia and is gradually emerging in Sub-Saharan Africa. Although nonsynonymous SNPs in the pfk13 Kelch-repeat propeller (KREP) domain are clearly associated with artemisinin resistance, their functional relevance requires cooperation with other genetic factors/alterations of the P. falciparum...
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