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Article

Plasmodium falciparum transcription factor AP2-06B is mutated at high frequency in Southeast Asia but does not associate with drug resistance.

Frontiers in cellular and infection microbiology - 1 Jan 2024

Shi Qiyang, Wang Changhong, Yang Wenluan, Ma Xiaoqin, Tang Jianxia, Zhang Jiayao, Zhu Guoding, Wang Yinlong, Liu Yaobao, He Xiaoqin

Abstract excerpt

Introduction: A continuing challenge for malaria control is the ability of Plasmodium falciparum to develop resistance to antimalarial drugs. Members within the Plasmodium transcription factor family AP2 regulate the growth and development of the parasite, and are also thought to be involved in unclear aspects of drug resistance. Here we screened for single nucleotide polymorphisms (SNPs) within the AP2 family...

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Identifiers

PMID: 39835275
DOI: 10.3389/fcimb.2024.1521152
PMCID: PMC11744005

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