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Article

Mutations in Plasmodium falciparum Kelch13 (PfK13) dysregulates PI3K/AKT signalling pathway in artemisinin resistance.

Indian journal of medical microbiology - 1 Jan 2024

Verma Kanika, Singh Yashika, Kamaraj Balu, Sharma Priyanka, Schneider Kristan Alexander, Bharti Praveen Kumar

Abstract excerpt

BACKGROUND: PfK13 protein mutations are associated with the emergence of artemisinin resistance in Plasmodium falciparum. PfK13 protein is essential for mediating ubiquitination and controlling the PI3K/AKT pathway. Mutant PfK13 variations can interfere with substrate binding, especially with PfPI3K, which raises PfPI3K levels. METHODS: DUET, DynaMut2, mCSM, iStable 2.0, I-Mutant 2.0, and MuPro were utilized to...

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PMID: 39079616
DOI: 10.1016/j.ijmmb.2024.100691

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