Article
Mutation in the Plasmodium falciparum BTB/POZ Domain of K13 Protein Confers Artemisinin Resistance.
Antimicrobial agents and chemotherapy - 18 Jan 2022
Paloque Lucie, Coppée Romain, Stokes Barbara H, Gnädig Nina F, Niaré Karamoko, Augereau Jean-Michel, Fidock David A, Clain Jérôme, Benoit-Vical Françoise
Abstract excerpt
Partial artemisinin resistance, defined in patients as a delayed parasite clearance following artemisinin-based treatment, is conferred by non-synonymous mutations in the Kelch beta-propeller domain of the Plasmodium falciparum k13 (pfk13) gene. Here, we carried out in vitro selection over a 1-year period on a West African P. falciparum strain isolated from Kolle (Mali) under a dose-escalating artemisinin...
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