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Article

Association of Polymorphisms in the Regulatory Region of the Cyclophilin a Gene (PPIA) with Gene Expression and HIV/AIDS Disease Progression.

Journal of acquired immune deficiency syndromes (1999) - 15 Aug 2016

Madlala Paradise, Singh Ravesh, An Ping, Werner Lise, Mlisana Koleka, Abdool Karim Salim S, Winkler Cheryl A, Ndungʼu Thumbi

Abstract excerpt

BACKGROUND: Human cyclophilin A (CypA) encoded by peptidyl prolyl isomerase A gene (PPIA), enhances HIV-1 replication by aiding capsid uncoating. The association of genetic variation in the PPIA regulatory region with susceptibility to HIV-1 infection, disease progression, and gene expression among black South Africans at risk for infection or infected with HIV-1 is unknown. METHODS: We genotyped 539 participants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27088296
DOI: 10.1097/QAI.0000000000001028
PMCID: PMC4942341

Genes

PPIA

Provenance

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