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Article

Enhanced cell stress response and protein degradation capacity underlie artemisinin resistance in Plasmodium falciparum.

mSphere - 21 Nov 2024

Rosenthal Melissa R, Vijayrajratnam Sukhithasri, Firestone Tessa M, Ng Caroline L

Abstract excerpt

Malaria remains a global health burden, killing over half a million people each year. Decreased therapeutic efficacy to artemisinin, the most efficacious antimalarial, has been detected in sub-Saharan Africa, a worrying fact given that over 90% of deaths occur on this continent. Mutations in Kelch13 are the most well-established molecular marker for artemisinin resistance, but these do not explain all...

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Antimalarials
Artemisinins
Malaria, Falciparum
Plasmodium falciparum
Proteasome Endopeptidase Complex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protozoan Proteins

Unfolded Protein Response

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Identifiers

PMID: 39436072
DOI: 10.1128/msphere.00371-24
PMCID: PMC11580438

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