Article
IDH mutation detection in formalin-fixed paraffin-embedded gliomas using multiplex PCR and single-base extension.
Brain pathology (Zurich, Switzerland) - 1 Sept 2012
Perizzolo Marco, Winkfein Bob, Hui Susan, Krulicki Wally, Chan Jennifer A, Demetrick Douglas J
Abstract excerpt
Isocitrate dehydrogenase (IDH) genes are mutated in a significant portion of gliomas, myeloid leukemias and chondroid neoplasms. In gliomas, IDH mutations are prognostic, as those tumors with the mutation are associated with a proneural subclass and have longer survival compared with those without the mutation. We developed a simple, PCR-based SNaPshot® assay (Life Technologies, Carlsbad, CA, USA) to detect...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.