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Glioma 2021 WHO Classification: The Superiority of NGS Over IHC in Routine Diagnostics.

Molecular diagnosis & therapy - 1 Nov 2022

Śledzińska Paulina, Bebyn Marek, Szczerba Ewelina, Furtak Jacek, Harat Maciej, Olszewska Natalia, Kamińska Katarzyna, Kowalewski Janusz, Lewandowska Marzena A

Abstract excerpt

INTRODUCTION: The accurate detection of genetic variants such as single substitutions (IDH1/2, TERT), chromosomal abnormalities (CDKN2A, 1p/19q deletions, and EGFR amplifications), or promoter methylations (MGMT) is critical for glioma patient management, as emphasized in the World Health Organization's (WHO's) most recent classification in 2021 (WHO CNS5). The purpose of this study was to evaluate novel...

Topics

Humans
Brain Neoplasms
Immunohistochemistry
Glioma
High-Throughput Nucleotide Sequencing
Mutation
World Health Organization
Isocitrate Dehydrogenase

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36053463
DOI: 10.1007/s40291-022-00612-3
PMCID: PMC9626418

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