Article
Predicting the likelihood of an isocitrate dehydrogenase 1 or 2 mutation in diagnoses of infiltrative glioma.
Neuro-oncology - 1 Nov 2014
Chen Li, Voronovich Zoya, Clark Kenneth, Hands Isaac, Mannas Jonathan, Walsh Meggen, Nikiforova Marina N, Durbin Eric B, Weiss Heidi, Horbinski Craig
Abstract excerpt
BACKGROUND: Several variables are associated with the likelihood of isocitrate dehydrogenase 1 or 2 (IDH1/2) mutation in gliomas, though no guidelines yet exist for when testing is warranted, especially when an R132H IDH1 immunostain is negative. METHODS: A cohort of 89 patients was used to build IDH1/2 mutation prediction models in World Health Organization grades II-IV gliomas, and an external cohort of 100...
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