Article
Development of a Rapid and Sensitive IDH1/2 Mutation Detection Method for Glial Tumors and a Comparative Mutation Analysis of 236 Glial Tumor Samples.
Molecular diagnosis & therapy - 1 Jun 2020
Avsar Timucin, Sursal Alihan, Turan Gizem, Yigit Berfu Nur, Altunsu Deniz, Cantasir Kutay, Duyu Gözde, Bayoumi Ahmed B, Yapicier Ozlem, Acar Melih, Kilic Turker
Abstract excerpt
BACKGROUND: The presence of mutations in the isocitrate dehydrogenase 1 and 2 genes (IDH1/2) in glioma tumors is correlated with good prognosis upon standard-of-care treatment. Therefore, information on whether the glioma tumor has IDH1/2 mutations could be used in the correct diagnosis and management of glial tumors. The two most common techniques used to detect IDH1/2 mutations, immunohistochemistry (IHC) and...
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