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Article

Going vertical: functional role and working principles of the protein Inscuteable in asymmetric cell divisions.

Cellular and molecular life sciences : CMLS - 1 Nov 2013

Culurgioni Simone, Mapelli Marina

Abstract excerpt

Coordinating mitotic spindle dynamics with cortical polarity is essential for stem cell asymmetric divisions. Over the years, the protein Inscuteable (Insc) has emerged as a key element determining the spindle orientation in asymmetric mitoses. Its overexpression increases differentiative divisions in systems as diverse as mouse keratinocytes and radial glial cells. To date, the molecular explanation to account...

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Identifiers

PMID: 23516018
DOI: 10.1007/s00018-013-1319-z
PMCID: PMC11113624

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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