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Article

STAT3 promotes a youthful epigenetic state in articular chondrocytes

13 Jan 2023

Abstract excerpt

Epigenetic mechanisms guiding articular cartilage regeneration and age-related disease such as osteoarthritis (OA) are poorly understood. STAT3 is a critical age-patterned transcription factor highly active in fetal and OA chondrocytes, but the context-specific role of STAT3 in regulating the epigenome of cartilage cells remain elusive. In this study, DNA methylation profiling was performed across human...

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PMID: 36638270
DOI: 10.1111/acel.13773

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