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Article

The methylomic landscape of human articular cartilage development contains epigenetic signatures of osteoarthritis risk.

American journal of human genetics - 5 Dec 2024

McDonnell Euan, Orr Sarah E, Barter Matthew J, Rux Danielle, Brumwell Abby, Wrobel Nicola, Murphy Lee, Overman Lynne M, Sorial Antony K, Young David A, Soul Jamie, Rice Sarah J

Abstract excerpt

Increasing evidence is emerging to link age-associated complex musculoskeletal diseases, including osteoarthritis (OA), to developmental factors. Multiple studies have shown a functional role for DNA methylation in the genetic mechanisms of OA risk using articular cartilage samples taken from aged individuals, yet knowledge of temporal changes to the methylome during human cartilage development is limited. We...

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Share to Cartilage, Articular
Share to Chondrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Methylation

Share to Epigenesis, Genetic

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Share to Quantitative Trait Loci

Source

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Identifiers

PMID: 39579763
DOI: 10.1016/j.ajhg.2024.10.017
PMCID: PMC11639090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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