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Article

Epigenetic mechanisms of osteoarthritis risk in human skeletal development

2024-05-06

Abstract excerpt

The epigenome, including the methylation of cytosine bases at CG dinucleotides, is intrinsically linked to transcriptional regulation. The tight regulation of gene expression during skeletal development is essential, with ∼1/500 individuals born with skeletal abnormalities. Furthermore, increasing evidence is emerging to link age-associated complex genetic musculoskeletal diseases, including osteoarthritis (OA), t...

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Literature Corpus work
0166c8a2-f37a-5bfa-a7f0-004257e06c95
DOI
10.1101/2024.05.05.24306832
Open publication

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Epigenetic mechanisms of osteoarthritis risk in human skeletal developmentDOI 10.1101/2024.05.05.24306832
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