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Article

Genetic risk of osteoarthritis operates during human skeletogenesis

9 Oct 2022

Abstract excerpt

Osteoarthritis (OA) is a polygenic disease of older people resulting in the breakdown of cartilage within articular joints. Although it is a leading cause of disability, there are no disease-modifying therapies. Evidence is emerging to support the origins of OA in skeletogenesis. Whereas methylation quantitative trait loci (mQTLs) co-localizing with OA genome-wide association study signals have been identified in...

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PMID: 36209419
DOI: 10.1093/hmg/ddac251

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