Article

Abnormal DNA methylation pattern and expression of DNA methyltransferase 1 promote synovitis and bone destruction in rheumatoid arthritis

2026-01-22

Abstract excerpt

<title>Abstract</title> <p>Background Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia and joint destruction, in which fibroblast-like synoviocytes (FLS) play a pivotal role. However, the epigenetic mechanisms underlying FLS activation remain incompletely understood. Methods DNA methylation chip sequencing and transcriptome sequencing were performed on FLS of RA an...

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Literature Corpus work: f39ffc20-bd41-5a11-8b59-17a0e4bf87d6
DOI: 10.21203/rs.3.rs-8601364/v1

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