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Article

Epigenetics as a mediator of genetic risk in osteoarthritis: role during development, homeostasis, aging, and disease progression.

American journal of physiology. Cell physiology - 1 May 2023

Richard Daniel, Capellini Terence D, Diekman Brian O

Abstract excerpt

The identification of genomic loci that are associated with osteoarthritis (OA) has provided a starting point for understanding how genetic variation activates catabolic processes in the joint. However, genetic variants can only alter gene expression and cellular function when the epigenetic environment is permissive to these effects. In this review, we provide examples of how epigenetic shifts at distinct life...

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Source

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Identifiers

PMID: 36971423
DOI: 10.1152/ajpcell.00574.2022
PMCID: PMC10191130

Genes

GDF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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