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Article

BDNF rs6265 differentially influences neurometabolites in the anterior cingulate of healthy and bipolar disorder subjects.

Brain imaging and behavior - 1 Jun 2023

Scotti-Muzzi Estêvão, Chile Thais, Vallada Homero, Otaduy Maria Concepción Garcia, Soeiro-de-Souza Márcio Gerhardt

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) is the most abundant brain neurotrophin and plays a critical role in neuronal growth, survival and plasticity, implicated in the pathophysiology of Bipolar Disorders (BD). The single-nucleotide polymorphism in the BDNF gene (BDNF rs6265) has been associated with decreased hippocampal BDNF secretion and volume in met carriers in different populations, although the val...

Topics

Male
Humans
Bipolar Disorder
Gyrus Cinguli
Brain-Derived Neurotrophic Factor
Magnetic Resonance Imaging
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36630045
DOI: 10.1007/s11682-023-00757-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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