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Association between CACNA1C gene rs100737 polymorphism and glutamatergic neurometabolites in bipolar disorder.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jun 2022

Scotti-Muzzi Estêvão, Chile Thais, Vallada Homero, Otaduy Maria Concepción Garcia, Soeiro-de-Souza Márcio Gerhardt

Abstract excerpt

Abnormalities in Ca2+ homeostasis in Bipolar Disorders (BD) have been associated with impairments in glutamatergic receptors and voltage-gated calcium channels. Increased anterior cingulate cortex (ACC) glutamatergic neurometabolites have been consistently disclosed in BD by proton magnetic resonance spectroscopy (1H-MRS). A single nucleotide polymorphism (SNP) in the CACNA1C gene (rs1006737), which encodes the...

Topics

Bipolar Disorder
Calcium Channels, L-Type
Female
Glutamic Acid
Glutamine
Gyrus Cinguli
Humans
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proton Magnetic Resonance Spectroscopy

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PMID: 35544990
DOI: 10.1016/j.euroneuro.2022.04.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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