Bcl-2 rs956572 polymorphism is associated with increased anterior cingulate cortical glutamate in euthymic bipolar I disorder.

doi:10.1038/npp.2012.203

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Bcl-2 rs956572 polymorphism is associated with increased anterior cingulate cortical glutamate in euthymic bipolar I disorder.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Feb 2013

Soeiro-de-Souza Márcio Gerhardt, Salvadore Giacomo, Moreno Ricardo Alberto, Otaduy Maria Concepción Garcia, Chaim Kalil T, Gattaz Wagner F, Zarate Carlos A, Machado-Vieira Rodrigo

Abstract excerpt

B-cell lymphoma 2 (Bcl-2) is an important regulator of cellular plasticity and resilience. In bipolar disorder (BD), studies have shown a key role for a Bcl-2 gene single-nucleotide polymorphism (SNP) rs956572 in the regulation of intracellular calcium (Ca(2+)) dynamics, Bcl-2 expression/levels, and vulnerability to cellular apoptosis. At the same time, Bcl-2 decreases glutamate (Glu) toxicity in neural cells....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bipolar Disorder

Share to Glutamic Acid

Share to Gyrus Cinguli

Share to Polymorphism, Single Nucleotide

Share to Proto-Oncogene Proteins c-bcl-2

Share to Up-Regulation

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 23072837
DOI: 10.1038/npp.2012.203
PMCID: PMC3547197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bcl-2 rs956572 polymorphism is associated with increased anterior cingulate cortical glutamate in euthymic bipolar I disorder.PMID 23072837Read ↗

ACC Glu/GABA ratio is decreased in euthymic bipolar disorder I patients: possible in vivo neurometabolite explanation for mood stabilization.Semantic proximity Read ↗

Association between CACNA1C gene rs100737 polymorphism and glutamatergic neurometabolites in bipolar disorder.Semantic proximity Read ↗

Bcl-2 SNP rs956572 associates with disrupted intracellular calcium homeostasis in bipolar I disorder.Semantic proximity Read ↗

BDNF rs6265 differentially influences neurometabolites in the anterior cingulate of healthy and bipolar disorder subjects.Semantic proximity Read ↗

CACNA1C SNP rs1006737 associates with bipolar I disorder independent of the Bcl-2 SNP rs956572 variant and its associated effect on intracellular calcium homeostasis.Semantic proximity Read ↗

The Bcl-2 gene polymorphism rs956572AA increases inositol 1,4,5-trisphosphate receptor-mediated endoplasmic reticulum calcium release in subjects with bipolar disorder.Semantic proximity Read ↗

GRIN2B gene and associated brain cortical white matter changes in bipolar disorder: a preliminary combined platform investigation.Semantic proximity Read ↗

Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humans.Semantic proximity Read ↗

Glutamate, NAA and Energy Metabolism in Clinical High Risk and First Episode PsychosisSemantic proximity Read ↗

Effect of Bcl-2 rs956572 SNP on regional gray matter volumes and cognitive function in elderly males without dementia.Semantic proximity Read ↗

Polymorphisms in the GAD2 gene-region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disorders.Semantic proximity Read ↗

Brain Arousal Regulation in Carriers of Bipolar Disorder Risk Alleles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.