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Article

Met carriers of BDNF Val66Met genotype show increased N-acetylaspartate concentration in the anterior cingulate cortex.

NeuroImage - 1 Jan 2010

Gallinat Jürgen, Schubert Florian, Brühl Rüdiger, Hellweg Rainer, Klär Andreas A, Kehrer Colin, Wirth Christoph, Sander Thomas, Lang Undine E

Abstract excerpt

Decreased levels of N-acetylaspartate (NAA) and brain-derived neurotrophic factor (BDNF) in the anterior cingulate cortex (ACC) have been linked to neuronal loss and psychiatric disorders like schizophrenia and bipolar disorder. We previously found that BDNF serum concentration was predicted by the concentration of NAA in the ACC, indicating that neuronal integrity and vitality of a cortical region like the ACC,...

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Source

Identifiers

PMID: 19683059
DOI: 10.1016/j.neuroimage.2009.08.018

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Met carriers of BDNF Val66Met genotype show increased N-acetylaspartate concentration in the anterior cingulate cortex.PMID 19683059Read ↗

Met carriers of the BDNF Val66Met polymorphism show reduced Glx/NAA in the pregenual ACC in two independent cohorts.Semantic proximity Read ↗

BDNF rs6265 differentially influences neurometabolites in the anterior cingulate of healthy and bipolar disorder subjects.Semantic proximity Read ↗

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Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system.Semantic proximity Read ↗

Val66Met polymorphism and BDNF levels in Alzheimer's disease patients in North Indian population.Semantic proximity Read ↗

Performance-related increases in hippocampal N-acetylaspartate (NAA) induced by spatial navigation training are restricted to BDNF Val homozygotes.Semantic proximity Read ↗

Association of human hippocampal neurochemistry, serotonin transporter genetic variation, and anxiety.Semantic proximity Read ↗

The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.Semantic proximity Read ↗

Brain-derived neurotrophic factor val66met polymorphism affects prefrontal energy metabolism in bipolar disorder.Semantic proximity Read ↗

BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects.Semantic proximity Read ↗

Association study of the decreased serum BDNF concentrations in amnestic mild cognitive impairment and the Val66Met polymorphism in Chinese Han.Semantic proximity Read ↗

BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects.Semantic proximity Read ↗

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