Article
Met carriers of the BDNF Val66Met polymorphism show reduced Glx/NAA in the pregenual ACC in two independent cohorts.
Scientific reports - 24 Mar 2021
Martens Louise, Herrmann Luisa, Colic Lejla, Li Meng, Richter Anni, Behnisch Gusalija, Stork Oliver, Seidenbecher Constanze, Schott Björn H, Walter Martin
Abstract excerpt
The Met allele of the Val66Met SNP of the BDNF gene (rs6265) is associated with impaired activity-dependent release of brain-derived neurotrophic factor (BDNF), resulting in reduced synaptic plasticity, impaired glutamatergic neurotransmission, and morphological changes. While previous work has demonstrated Val66Met effects on magnetic resonance spectroscopy (MRS) markers of either glutamatergic metabolism (Glx)...
Topics
- Alleles
- Amino Acid Substitution
- Brain Waves
- Brain-Derived Neurotrophic Factor
- Female
- Genetic Association Studies
- Genotype
- Glutamic Acid