Brain-derived neurotrophic factor val66met polymorphism affects prefrontal energy metabolism in bipolar disorder.

doi:10.1097/WNR.0b013e3282ef7082

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Brain-derived neurotrophic factor val66met polymorphism affects prefrontal energy metabolism in bipolar disorder.

Neuroreport - 8 Oct 2007

Frey Benicio N, Walss-Bass Consuelo, Stanley Jeffrey A, Nery Fabiano G, Matsuo Koji, Nicoletti Mark A, Hatch John P, Bowden Charles L, Escamilla Michael A, Soares Jair C

Abstract excerpt

Brain-derived neurotrophic factor val66met polymorphism has been implicated in the pathophysiology of bipolar disorder. We investigated the neurochemistry of the left dorsolateral prefrontal cortex of bipolar disorder and healthy participants in relation to the brain-derived neurotrophic factor val66met polymorphism using H-magnetic resonance spectroscopy. Absolute N-acetyl-aspartate, phosphocreatine+creatine...

Topics

Adult
Amino Acid Substitution
Aspartic Acid
Bipolar Disorder
Brain-Derived Neurotrophic Factor
Creatine
Energy Metabolism
Female
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Magnetic Resonance Spectroscopy

Male

Methionine

Phosphocreatine

Polymorphism, Genetic

Prefrontal Cortex

Psychiatric Status Rating Scales

Valine

Source

Open in PubMed

Identifiers

PMID: 17885603
DOI: 10.1097/WNR.0b013e3282ef7082

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brain-derived neurotrophic factor val66met polymorphism affects prefrontal energy metabolism in bipolar disorder.PMID 17885603Read ↗

Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system.Semantic proximity Read ↗

BDNF rs6265 differentially influences neurometabolites in the anterior cingulate of healthy and bipolar disorder subjects.Semantic proximity Read ↗

Role of BDNF in bipolar and unipolar disorder: clinical and theoretical implications.Semantic proximity Read ↗

Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder.Semantic proximity Read ↗

Brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism differentially predicts hippocampal function in medication-free patients with schizophrenia.Semantic proximity Read ↗

Hippocampal volumes and the brain-derived neurotrophic factor val66met polymorphism in geriatric major depression.Semantic proximity Read ↗

Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease.Semantic proximity Read ↗

The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression.Semantic proximity Read ↗

Bipolar disorder, brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and brain morphology.Semantic proximity Read ↗

The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression.Semantic proximity Read ↗

Met carriers of BDNF Val66Met genotype show increased N-acetylaspartate concentration in the anterior cingulate cortex.Semantic proximity Read ↗

Val66met polymorphism and serum brain-derived neurotrophic factor levels in bipolar disorderSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.